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Scientific
research regarding Omega-3 Fatty Acids and the Brain*.
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Katzman, R., and J. E. Jackson. "Alzheimer disease: Basic and clinical
advances." J Am Geriatrics Soc 39:516-525 (1991).
Kodas E., Page G., Zimmer L., Vancassel S., Guilloteau D., Durand G.,
Chalon S. "Neither the density nor function of striatal dopamine
transporters were influenced by chronic n-3 polyunsaturated fatty acid
deficiency in rodents.” Neurosci Lett 321(1-2):95-9 (2002).
Kyle, D. J., E. Schaefer, G. Patton, and A. Beiser. "Low serum
docosahexaenoic acid is a significant risk factor for Alzheimer's
dementia." Lipids 34:S245 (1999).
Lauritzen, I., N. Blondeau, C. Heurteaux, C. Widmann, G. Romey, and M.
Lazdunski. "Polyunsaturated fatty acids are potent neuroprotectors."
EMBO J 19:1784-1793 (2000).
Gamoh, S., M. Hashimoto, K. Sugioka, S.
Hossain, N. Hata, Y. Misawa, and S. Masumura. "Chronic administration of
docosahexaenoic acid improves reference memory-related learning ability
in young rats." Neurosci 93:237-241 (1999).
Jones, C. R., T. Aria, and S. I. Rapoport. "Evidence for the involvement
of docosahexaenoic acid in cholinergic simulated signal transduction at
the synapse." J Neurochem Res 22:663-670 (1997).
Burgress, J. R., L. Stevens, and L. Peck. "Long-chain polyunsaturated
fatty acids in children with attention-deficit hyperactivity disorder."
Am J Clin Nutr 71:327S-330S (2000).
Connor, W. E., M. Neuringer, and D. S. Lin. "Dietary effects on brain
fatty acid composition: The reversibility of n-3 fatty acids deficiency
and turnover of docosahexaenoic acid in the brain erythrocytes and
plasma of rhesus monkeys." J Lipid Res 31:237-247 (1990).
Connor, W. E., M. Neuringer, and S. Reisbick. "Essential fatty acids:
Importance of n-3 fatty acids in the retina and brain." Ntr Rev
50:21-29 (1992).
Conquer, J. A., M. C. Tierney, J. Zecevic, W.J. Bettger, and R.H.
Fisher. "Fatty acid analysis of blood plasma of patients with
Alzheimer's disease, other types of dementia, and cognitive impairment."
Lipids 35:1305-1312 (2000).
Fenton W. ., Dickerson F., Boronow J., Hibbeln J. R., Knable M. “A
placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic
acid) supplementation for residual symptoms and cognitive impairment in
schizophrenia.” Am J Psychiatry 158(12):2071-4 (2001).
Lauritzen, L., H. S. Hansen, M. H. Jorgensen, and K. F. Michaelsen. "The
essentiality of long-chain n-3 fatty acids in relation to development
and function of the brain and retina." Prog Lipid Res 40:1-94
(2001).
Marangell L B, Martinez J M, Zboyan H A, Kertz B, Kim H F, Puryear L J.
“A double-blind, placebo-controlled study of the omega-3 fatty acid
docosahexaenoic acid in the treatment of major depression.” Mood
Disorders Center, Department of Psychiatry, Baylor College of Medicine,
Houston, TX, USA. Voigt, R. G., A.
M. Llorente, C. L. Jensen, J. K. Fraley, M.C. Berretta, and W. C. Heird.
"A randomized, double-blind, placebo-controlled trial of docosahexaenoic
acid supplementation in children with attention-deficit/hyperactivity
disorder." J Pediatr 139:189-196 (2001).
Vance, H. E., R. B. Campenot, and D. E. Vance. "The synthesis and
transport of lipids for axonal growth and nerve regeneration."
Biochim Biophys Acta 1486:84-96 (2000).
Yeh, Y. Y., M. F. Gehman, and S. M. Yeh. "Maternal dietary fish oil
enriches docosahexaenoate levels in brain subcellular fractions of
offspring." J Neurosci Res 35:218-226 (1993).
Yehuda, S., S. Rabinovitz, R.L. Carasso, and D.I. Mostofsky. "Essential
fatty acid preparation improves Alzheimer's patients' quality of life."
Int J Neurosci 87:141-149 (1996).
Schiefermeier M., Yavin E. “n-3
Deficient and docosahexaenoic acid-enriched diets during critical
periods of the developing prenatal rat brain.” J Lipid Res
43(1):124-31 (2002).
Sonderberg, M., C. Edlund, K. Kristensson, and G. Dallner. "Fatty acid
composition of brain phospholipids in aging and Alzheimer's disease."
Lipids 26:421-423 (1991).
Stevens, L. J., and J. Burgess. "Omega-3 fatty acids in boys with
behavior, learning, and health problems." Physiol Behav
59:915-920 (1996).
Stordy, B. J. "Benefit of docosahexaenoic acid supplements to dark
adaption in dyslexics." Lancet 346:385 (1995).
Terano, T., S. Fujishiro, T. Ban, K. Yamamoto, T. Tanaka, Y. Noguchi, Y.
Tamura, K. Yazawa, and T. Hirayama. "Docosahexaenoic acid
supplementation improves moderately severe dementia from thromboitc
cerebrovascular diseases. Lipids 34:S345-S346 (1999).
Willatts, P., J. S. Forsyth, M. K. DiModugno, S. Varma, and M. Colvin.
“Effect of long-chain polyunsaturated fatty acids in infant formula on
problem solving at 10 months of age.” Lancet 352:688-691 (1998).
Stevens, L. J., S. S. Zentall, J. L. Deck, M. L. Abate, B. A. Watkins,
S. A. Lipp, and J. R. Burgess. "Essential fatty acid metabolism in boys
with attention-deficit hyperactivity disorder." Am J Clin Nutr
62:761-768 (1995).
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